蛋白的NF-kappa-b（nfkb）復合物被I-kappa-b（ikb）蛋白抑制，通過將其捕獲在細胞質中使nfkb失活。IKB激酶對IKB蛋白絲氨酸殘基的磷酸化標記它們通過泛素化途徑被破壞，從而允許NFKB復合體的活化和核易位。該基因編碼的蛋白質類似于IKB激酶，可以調節NFKB的激活以響應某些生長因子。
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.