這個基因編碼一個轉錄因子家族成員。ets蛋白調節許多靶基因，這些靶基因調節細胞生長、血管生成、遷移、增殖和分化等生物學過程。所有的ets蛋白都含有一個ets-dna結合域，該域結合到含有共識5’-cgga[at]-3’的dna序列。該基因編碼的蛋白質除了在C末端區域的ets-dna結合域外，在N末端區域還含有一個保守的短酸性激活域（tad）。該基因參與染色體易位，導致多個融合蛋白，包括Erwing肉瘤中的ews-etv1和前列腺癌中至少10個etv1伙伴（見pmid:19657377，表1）。除染色體重排外，該基因在前列腺癌、黑色素瘤和胃腸道間質瘤中過表達。已經鑒定出編碼不同亞型的多個選擇性剪接轉錄變體。
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.