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    發布時間:2022-07-13 15:50 原文鏈接: 轉化生長因子β信號通路相關的基因介紹PPP2R1A基因

    該基因編碼蛋白質磷酸酶2的恒定調節亞單位。蛋白磷酸酶2是四種主要的ser/thr磷酸酶之一,與細胞生長和分裂的負調控有關。它由一種常見的異聚核心酶組成,由一個催化亞基和一個恒定的調節亞基組成,與多種調節亞基相結合。恒定調節亞基a充當支架分子,以協調催化亞基和可變調節b亞基的組裝。該基因編碼恒定調節亞單位a的α亞型。已描述了選擇性剪接的轉錄變體。[由RefSeq提供,2010年4月]
    This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

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