蘋果酸脫氫酶在檸檬酸循環中利用NAD/NADH輔因子體系催化蘋果酸對草酰乙酸的可逆氧化。由該基因編碼的蛋白質定位于線粒體，可能在蘋果酸-天冬氨酸穿梭中發揮關鍵作用，在細胞溶膠和線粒體之間的代謝協調中起作用已經發現了一些編碼不同亞型的轉錄變體。[由RefSeq提供，2013年9月]
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]